Clinical trials involving carbon‐ion radiation therapy and the path forward

Design of clinical trials of radiation combined with antiangiogenic therapy.

Clinical trials showing longer survival when chemotherapy is combined with antiangiogenic agents (AAs) have led to growing interest in designing combined modality protocols that exploit abnormalities in tumor vasculature. Approved agents include bevacizumab, a recombinant monoclonal antibody that binds to vascular endothelial growth factor, and two small molecule multitargeted tyrosine kinase i...

Therapy and clinical trials.

The year 2011 has thus far been dominated by the vigorous pursuit of interventions for patients with low levels of high-density lipoprotein cholesterol (HDL-C) and proatherogenic lipid profiles. The major setback of the early stoppage of the Atherothrombosis Intervention in Metabolic Syndrome with Low HDL Cholesterol/ High Triglyceride and Impact on Global Health Outcomes (AIM-HIGH) trial by th...

Registration of clinical trials: a step forward but still a long path ahead.

Involving South Asian patients in clinical trials.

OBJECTIVES To investigate how South Asian patients conceptualise the notion of clinical trials and to identify key processes that impact on trial participation and the extent to which communication difficulties, perceptions of risk and attitudes to authority influence these decisions. Also to identify whether 'South Asian' patients are homogeneous in these issues, and which factors differ betwe...

CURRENTOPINION Therapy and clinical trials

DOI:10.1097/MOL.0000000000000151 The link between triglyceride levels and cardiovascular disease was first described several decades ago. Several high-quality observational studies and clinical trials [1,2 & ,3–5,6 && ,7,8] have since demonstrated that elevated levels of triglycerides are associated with an increased risk of cardiovascular disease, myocardial infarction, stroke and all-cause mo...